Nel 2002 giunse l'approvazione per l'uso in medicina estetica for every il miglioramento temporaneo delle rughe di espressione fra le sopracciglia (linee glabellari). La tossina botulinica agisce inibendo il rilascio del neurotrasmettitore acetilcolina: bloccandone il rilascio nei muscoli non si manifestano rughe, spasmi o tic facciali e smagliatur
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